1、Macroporous polymeric resin for the purification of flavonoids from

The purification of flavonoids using the macroporous polymer resin method has gained attention in recent years due to its simplicity, precision, cost-effectiveness, and the ability to separate flavonoids from other constituents.

2、Multi

UP/UA synergy boosts flavonoid adsorption via multi-mechanism physical modification. Ultrasound may effectively enhance mass transfer in macroporous resin adsorption/desorption for flavonoid purification.

3、Full article: Macroporous resin purification and quantification by LC

Ginkgo biloba leaves (GBL), a traditional Chinese medicinal resource, are recognised for their rich flavonoid content with diverse bioactivities. This study optimised the purification of total flavonoids from GBL using macroporous adsorption resin and quantified the compounds via LC-MS.

4、Modified macroporous adsorption resin (LX1180) used to

Purpose – The purpose of this paper is to prepare a higher chloromethylation degree (CD) modified macroporous adsorption resin (MAR, LX1180-Cl) and further study their adsorption performance.

Macroporous Resin Purifies Total Flavonoids of Mosla Dianthera with

RESULTS The optimal process conditions for macroporous resin enrichment and purification of total flavonoids of Mosla dianthera were as follows: HPD-300 macroporous resin was selected, the maximum loading amount was 72 mg·g −1, the adsorption time was 100 min, the adsorption temperature was 25 ℃, 60% ethanol was used, and the flow rate was ...

Macroporous polymeric resin for the purification of flavonoids from

The purification of flavonoids using the macroporous polymer resin method has gained attention in recent years due to its simplicity, precision, cost‐effectiveness, and the ability to separate flavonoids from other constituents.

Macroporous polymeric resin for the purification of flavonoids from

Several studies have been conducted to investigate the efficiency and effectiveness of macroporous polymer resin in purifying flavonoids from various plant sources.

Macroporous polymeric resin for the purification of flavonoids

Macroporous polymeric resin for the purification of flavonoids from medicinal plants: A review - 科研通

Application of the selected macroporous resin for the

A systematic investigation was conducted on the adsorption and desorption properties of macroporous resins including D101, ADS7, HPD600, XAD2 and HPD100 for flavonoids of Radix Pueraria Lobata.

Ultrasound

The work explored the process of ultrasound-assisted adsorption/desorption to efficiently purify jujube peel flavonoids (JPFs) using macroporous resins (MRs). The impact of ultrasound power and temperature on the adsorption/desorption features of JPFs on MRs were studied.

In modern pharmaceutical and biotechnological fields, flavonoids have garnered significant attention due to their diverse biological activities. Not only do they play crucial roles in natural products, but they also exhibit immense potential in drug development and disease treatment. the poor water solubility of flavonoids remains a major limitation to their further research and application. finding effective methods to enhance the water solubility of flavonoids is critical to advancing their use in the pharmaceutical industry. Macroporous resins, as highly efficient adsorbents, offer a novel approach to flavonoid modification due to their unique pore structures and excellent chemical stability.

Flavonoids, a broad class of polyphenolic compounds widely found in nature, possess various physiological activities, including antioxidant, anti-inflammatory, antiviral, and anticancer properties. These characteristics make flavonoids an important focus in pharmaceutical research. their poor water solubility has long been a primary constraint on their widespread application. To address this challenge, researchers have begun exploring various methods to improve the water solubility of flavonoids. Among these, macroporous resins have been widely used in flavonoid modification studies due to their superior performance as adsorbents.

Macroporous resins are high-surface-area polymeric materials with well-defined pore structures. Their wide range of pore sizes allows them to adsorb large amounts of water and other small molecules, enabling effective separation and purification of target compounds. During flavonoid modification, macroporous resins can chemically react with flavonoid molecules through functional groups such as hydroxyl and carboxyl groups on their surfaces, forming stable bonds that enhance water solubility. Additionally, by adjusting the surface properties of the resin, such as hydrophilicity and hydrophobicity, the dispersion and stability of flavonoid molecules in water can be regulated.

For example, in studies on macroporous resin-modified flavonoids, researchers first selected several commonly used resins, including sulfonated, quaternary ammonium, and phosphate types, and modified them. Surface modifications, such as introducing hydrophilic groups or altering the resin’s structural morphology, effectively improved the resin’s surface hydrophilicity, thereby enhancing its adsorption capacity for flavonoids. Meanwhile, by regulating the pore size of the resin, the diffusion rate of flavonoid molecules within the resin could be controlled, achieving selective adsorption and desorption of flavonoids.

Experimental results demonstrated that macroporous resin-modified flavonoids significantly improved water solubility. Specifically, the water solubility of modified flavonoids increased by several to more than ten times while retaining good biological activity. This achievement not only provides new insights and methods for the development of flavonoid-based drugs but also offers valuable references for the modification of other compounds with similar properties.

Beyond improving water solubility, macroporous resin-modified flavonoids hold additional potential applications. For instance, by adjusting resin properties, directional adsorption and desorption of flavonoid molecules can be achieved, optimizing their performance in pharmaceutical formulations. Furthermore, macroporous resins can be used for the separation, purification, and analytical detection of flavonoids, providing critical support for quality control and efficacy evaluation.

Looking ahead, research on macroporous resin-modified flavonoids will continue to advance. On one hand, synthesizing new macroporous resin materials could further enhance adsorption capacity and selectivity for flavonoids. On the other hand, exploring a broader range of modification methods could meet the demands of diverse application scenarios. Concurrently, strengthening studies on the bioactivity and pharmacological effects of modified flavonoids will lay a solid foundation for their use in medicine.

research on macroporous resin-modified flavonoids offers fresh perspectives and methodologies for the development and application of flavonoid-based drugs. By improving water solubility, optimizing performance in pharmaceutical formulations, and expanding potential applications in other fields, macroporous resin-modified flavonoids are poised to play a greater role in the future, contributing more to human health.